Publication:
The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut

Simple item page
dc.contributor.authorAlbert, Korin
dc.contributor.authorRani, Asha
dc.contributor.authorSela, David A.
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.date2023-09-23T21:45:29.000
dc.date.accessioned2024-04-26T17:31:47Z
dc.date.available2018-08-17T00:00:00Z
dc.date.issued2018-01-01
dc.description.abstractBifidobacterium is a diverse genus of anaerobic, saccharolytic bacteria that colonize many animals, notably humans and other mammals. The presence of these bacteria in the gastrointestinal tract represents a potential coevolution between the gut microbiome and its mammalian host mediated by diet. To study the relationship between bifidobacterial gut symbionts and host nutrition, we analyzed the genome of two bifidobacteria strains isolated from the feces of a common marmoset (Callithrix jacchus), a primate species studied for its ability to subsist on host-indigestible carbohydrates. Whole genome sequencing identified these isolates as unique strains of Bifidobacterium callitrichos. All three strains, including these isolates and the previously described type strain, contain genes that may enable utilization of marmoset dietary substrates. These include genes predicted to contribute to galactose, arabinose, and trehalose metabolic pathways. In addition, significant genomic differences between strains suggest that bifidobacteria possess distinct roles in carbohydrate metabolism within the same host. Thus, bifidobacteria utilize dietary components specific to their host, both humans and non-human primates alike. Comparative genomics suggests conservation of possible coevolutionary relationships within the primate clade.
dc.identifier.doihttps://dx.doi.org/10.1099/mgen.0.000183
dc.identifier.urihttps://hdl.handle.net/20.500.14394/29644
dc.relation.ispartofMicrobial Genomics
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1008&context=foodsci_faculty_pubs&unstamped=1
dc.rightsUMass Amherst Open Access Policy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.issue4
dc.source.statuspublished
dc.subjectbifidobacteria
dc.subjectcomparative genomics
dc.subjectgut microbiota
dc.subjectcommensalism
dc.subjectnon-human primate
dc.titleThe comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut
dc.typearticle
dc.typearticle
digcom.contributor.authorAlbert, Korin
digcom.contributor.authorRani, Asha
digcom.contributor.authorisAuthorOfPublication|email:davidsela@umass.edu|institution:University of Massachusetts Amherst|Sela, David A.
digcom.date.embargo2018-08-17T00:00:00-07:00
digcom.identifierfoodsci_faculty_pubs/9
digcom.identifier.contextkey12680654
digcom.identifier.submissionpathfoodsci_faculty_pubs/9
dspace.entity.typePublication
relation.isAuthorOfPublication46d5d02f-51c4-436d-ab3e-7c6790a55fef
relation.isAuthorOfPublication.latestForDiscovery46d5d02f-51c4-436d-ab3e-7c6790a55fef
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
mgen000183.pdf
Size:
2.5 MB
Format:
Adobe Portable Document Format
Thumbnail Image
Name: mgen000183.pdf
Size: 2.5 MB
Kind: Adobe PDF
Collections
Food Science Department Faculty Publication Series