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Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age

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dc.contributor.authorRietman, Edward A.
dc.contributor.authorTaylor, Sophie
dc.contributor.authorSiegelmann, Hava T.
dc.contributor.authorDeriu, Marco A.
dc.contributor.authorCavaglia, Marco
dc.contributor.authorTuszynski, Jack A.
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Alberta
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentDIMEAS
dc.contributor.departmentDIMEAS
dc.contributor.departmentUniversity of Alberta
dc.date2023-09-24T07:22:56.000
dc.date.accessioned2024-04-26T09:34:19Z
dc.date.available2021-10-04T00:00:00Z
dc.date.issued2020-01-01
dc.description.abstractWe propose to use a Gibbs free energy function as a measure of the human brain development. We adopt this approach to the development of the human brain over the human lifespan: from a prenatal stage to advanced age. We used proteomic expression data with the Gibbs free energy to quantify human brain’s protein–protein interaction networks. The data, obtained from BioGRID, comprised tissue samples from the 16 main brain areas, at different ages, of 57 post-mortem human brains. We found a consistent functional dependence of the Gibbs free energies on age for most of the areas and both sexes. A significant upward trend in the Gibbs function was found during the fetal stages, which is followed by a sharp drop at birth with a subsequent period of relative stability and a final upward trend toward advanced age. We interpret these data in terms of structure formation followed by its stabilization and eventual deterioration. Furthermore, gender data analysis has uncovered the existence of functional differences, showing male Gibbs function values lower than female at prenatal and neonatal ages, which become higher at ages 8 to 40 and finally converging at late adulthood with the corresponding female Gibbs functions.
dc.identifier.doihttps://doi.org/10.3390/ijms21031116
dc.identifier.urihttps://hdl.handle.net/20.500.14394/9775
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2352&context=cs_faculty_pubs&unstamped=1
dc.rightsUMass Amherst Open Access Policy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.issue3
dc.source.issue21
dc.source.statuspublished
dc.subjectbrain development
dc.subjectGibbs free energy
dc.subjectthermodynamics
dc.subjecttranscriptome
dc.subjectprotein–protein interactions
dc.titleUsing the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age
dc.typearticle
dc.typearticle
digcom.contributor.authorisAuthorOfPublication|email:erietman@gmail.com|institution:University of Massachusetts Amherst|Rietman, Edward A.
digcom.contributor.authorisAuthorOfPublication|email:trageser@ualberta.ca|institution:University of Alberta|Taylor, Sophie
digcom.contributor.authorisAuthorOfPublication|email:hava@cs.umass.edu|institution:University of Massachusetts Amherst|Siegelmann, Hava T.
digcom.contributor.authorisAuthorOfPublication|email:deriu.marco@gmail.com|institution:DIMEAS|Deriu, Marco A.
digcom.contributor.authorisAuthorOfPublication|email:marco.cavaglia@fastwebnet.it|institution:DIMEAS|Cavaglia, Marco
digcom.contributor.authorisAuthorOfPublication|email:jackt@ualberta.ca|institution:University of Alberta|Tuszynski, Jack A.
digcom.date.embargo2021-10-04T00:00:00-07:00
digcom.identifiercs_faculty_pubs/1352
digcom.identifier.contextkey25260702
digcom.identifier.submissionpathcs_faculty_pubs/1352
dspace.entity.typePublication
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