Sketch-to-photo synthesis usually faced the problem of lack of labeled data, so we propose some methods based on CycleGAN to train a model to translate sketch to photo with unpaired data. Our main contribution is a proposed Sketch-to-Skeleton-to-Image (SSI) method, which performs skeletonization on sketches to reduce variance on the sketch data. We also tried different representations of the skeleton and different models for our task. Experiment results show that the generated image quality has a negative correlation with the sparsity of the input data.