Abstract. The potential health benefits of cranberries (Vaccinium macrocarpon) can be attributed to a variety of secondary metabolites, including proanthocyanidins (PACs), flavonoids, organic acids, and triterpenoids. Commercial cranberry supplements can provide a low-sugar alternative to juices and sweetened fruit products, however the phytochemical content can be expected to vary due to widely differing manufacturing processes. Selected commercial cranberry supplements were analyzed for secondary metabolite profile in comparison to a whole cranberry powder reference standard material, using 1H qNMR with Bruker AssureNMR software. HPLC-DAD and the DMAC assay were employed for total anthocyanin and PAC content respectively. Principal component analysis of 1H NMR spectra showed overlap between several supplements and whole cranberry powder, whereas others varied widely from the standard. Total PAC content varied widely, with four supplements ranging 5 - 10 mg PAC/g dry weight, one at 100 mg PAC/g dry weight, and insignificant PAC content in the rest. Several supplements contained only minimal amounts of organic acids and flavonoids. Cranberry peel constituents ursolic acid (8.0-16.3 mg/g) and oleanolic acid (0.3-5.1 mg/g), were detected in the whole cranberry reference standard but only about half of the supplements. Study results suggest significant variation in phytochemical composition among commercial cranberry supplements, reinforcing the need for reliable industry standards. This poster is not available for downloading.