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The Role of Hypothalamic Vasopressin Cells in Male Sociability and Anxiety-Linked Behavior

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dc.contributor.advisorJoseph F. Bergan
dc.contributor.advisorElena Vazey
dc.contributor.advisorHeather Richardson
dc.contributor.authorNanda, Prakruti
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentNeuroscience & Behavior
dc.date2024-03-28T20:31:26.000
dc.date.accessioned2024-04-26T18:25:07Z
dc.date.available2024-04-26T18:25:07Z
dc.date.submittedSeptember
dc.date.submitted2018
dc.description.abstractThe vertebrate hypothalamus is a central node within multiple interwoven neural networks that integrate external and internal cues to control homeostasis, endocrine functions and social behavior. The neuropeptide hormone arginine-vasopressin (AVP) is produced in both the supraoptic and paraventricular nuclei of the hypothalamus. Expression within these nuclei is conserved across species, and species differences in the expression of AVP and its cognate receptors correlate with differences in social behavior. As a central node within the social behavior network, chemogenetic manipulation of AVP+ cells in the paraventricular nucleus (pvn) of the hypothalamus provides a unique opportunity to investigate the relationship between social behavior and the regulation of stress responses. Here, we show that reversibly inducing excitatory activity in vasopressin neurons in the PVN results in reduced motivation for social interaction and increased grooming behavior in males. Chronic activation of PVN AVP neurons reduced social motivation in male mice that persisted even without CNO administration. These results highlight the role PVN AVP+ neurons play in the modulation of male social motivation.
dc.description.degreeMaster of Science (M.S.)
dc.identifier.doihttps://doi.org/10.7275/12766420
dc.identifier.orcidN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14394/33730
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1764&context=masters_theses_2&unstamped=1
dc.source.statuspublished
dc.subjectVasopressin
dc.subjectsociability
dc.subjecthypothalamus
dc.subjectBehavioral Neurobiology
dc.titleThe Role of Hypothalamic Vasopressin Cells in Male Sociability and Anxiety-Linked Behavior
dc.typeopenaccess
dc.typearticle
dc.typethesis
digcom.contributor.authorisAuthorOfPublication|email:prakrutinanda@gmail.com|institution:University of Massachusetts Amherst|Nanda, Prakruti
digcom.identifiermasters_theses_2/689
digcom.identifier.contextkey12766420
digcom.identifier.submissionpathmasters_theses_2/689
dspace.entity.typePublication
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