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A Precise Steroid-responsive Centrifugal Feedback Projection to the Accessory Olfactory Bulb

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dc.contributor.advisorJoseph Bergan
dc.contributor.advisorMariana Pereira
dc.contributor.advisorLuke Remage-Healey
dc.contributor.authorInbar, Tal
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentNeuroscience & Behavior
dc.date2024-03-28T20:46:20.000
dc.date.accessioned2024-04-26T18:25:08Z
dc.date.available2024-04-26T18:25:08Z
dc.date.submittedSeptember
dc.date.submitted2018
dc.description.abstractThe accessory olfactory bulb (AOB) processes pheromonal signals which in turn drive social behaviors. Here we identify a tract of aromatase-expressing (arom+) fibers in the dorsal lateral olfactory tract (dLOT) which terminate in the granule cell layer (GCL) of the AOB. We utilized a retrograde tracer in aromatase reporter animals to delineate the source of these fibers. We show that these input fibers emerge almost exclusively from a contiguous population of arom+ neurons that spans the bed nucleus of the accessory olfactory tract (BAOT) and posterioventral subnucleus of the medial amygdala (MeApv). This population of neurons expresses the estrogen receptor alpha and contains more aromatase neurons in male mice than female mice. Thus, this population of feedback neurons can detect neuroendocrine changes and modulate the output of AOB projection neurons in a way that is sexually dimorphic and could influence every downstream target of the AOB.
dc.description.degreeMaster of Science (M.S.)
dc.identifier.doihttps://doi.org/10.7275/12766050
dc.identifier.orcidN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14394/33732
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1763&context=masters_theses_2&unstamped=1
dc.source.statuspublished
dc.subjectAOB
dc.subjectfeedback
dc.subjectaromatase
dc.subjectBAOT
dc.subjectMeApv
dc.subjectSocial Behavior
dc.subjectBehavioral Neurobiology
dc.subjectNeuroscience and Neurobiology
dc.subjectSystems Neuroscience
dc.titleA Precise Steroid-responsive Centrifugal Feedback Projection to the Accessory Olfactory Bulb
dc.typeopenaccess
dc.typearticle
dc.typethesis
digcom.contributor.authorisAuthorOfPublication|email:tal.inbar8@gmail.com|institution:University of Massachusetts Amherst|Inbar, Tal
digcom.identifiermasters_theses_2/690
digcom.identifier.contextkey12766050
digcom.identifier.submissionpathmasters_theses_2/690
dspace.entity.typePublication
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