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ORCID
https://orcid.org/0009-0007-2297-3910
Access Type
Open Access Thesis
Document Type
thesis
Degree Program
Food Science
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2023
Month Degree Awarded
September
Abstract
P iperine is an alkaloid found in pepper plant, w hich exhibits many health benefits including anti aging, anti cancer, anti diabetic, and anti inflammatory effects. However, the anti obesity research of piperine is limited. Therefore, th is study was done to determine the effects of piperine on fat accumulation, using in vivo model, Caenor habditis elegans . Treatment with 100 μ M piperine reduce fat content of wild type C. elegans by 17% over control. Pumping rate was not affected by piperine, suggesting piperine has no effects on food intake of worms. Mutant strains were tested to determine t he fat reducing mechanisms. daf 2 , daf 12 , and daf 12 mutant strains failed to decrease the fat content by piperine, suggesting piperine may regulates fat accumulation via DAF 2, DAF 12, and DAF 16.
DOI
https://doi.org/10.7275/35980187.0
First Advisor
Yeonhwa Park
Recommended Citation
Teng, Zhoutai, "Fat Lowering Effects of Piperine in Caenorhabditis elegans" (2023). Masters Theses. 1346.
https://doi.org/10.7275/35980187.0
https://scholarworks.umass.edu/masters_theses_2/1346