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ORCID
https://orcid.org/0000-0003-0048-0166
Access Type
Open Access Thesis
Document Type
thesis
Embargo Period
2-1-2025
Degree Program
Chemical Engineering
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2024
Month Degree Awarded
February
Abstract
Approximately 17,000 people sustain a spinal cord injury (SCI) in the U.S. each year, and over a quarter million Americans currently live with paralysis due to SCI. Injury severity and functional deficits due to SCI correlate with the extent of fluid accumulation (i.e., edema) occurring immediately after injury. Previous studies showed fluid pressure around the injured spinal cord (supraspinal) remains elevated for at least three days and contributes to a phase of tissue damage known as secondary injury. While neural cells will more directly interface with fluid within the spinal cord (interstitial), it is currently unknown how SCI affects interstitial fluid pressure and if interstitial forces also contribute to secondary injury. In this project, I will use a combination of in silico and in vivo models to address these questions. Understanding the contributions of fluid forces and flows after SCI may enable strategies to limit tissue damage and functional deficits after SCI.
First Advisor
Chase Cornelison
Second Advisor
Ashish Kulkarni
Third Advisor
Shelly Peyton
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Kwon, Hoi, "Experimentally and Computationally Analyzing Interstitial Flow After Spinal Cord Injury" (2024). Masters Theses. 1408.
https://scholarworks.umass.edu/masters_theses_2/1408