Doctor of Nursing Practice (DNP) Projects

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Open Access

Degree Program

Doctor of Nursing Practice

Degree Track

Post Master's DNP Completion

Year Degree Awarded



Month Degree Awarded



Pharmacogenomics, psychiatry, major depression, nursing, innovation adoption


Pamela Aselton PhD, MPH, FNP-BC

DNP Project Chair

Pamela Aselton PhD, MPH, FNP-BC

DNP Project Member Name

Jeungok Choi, RN, PhD MPH

DNP Project Outside Member Name

Louis A. Velazquez, MD, DFAPA



Background: Treatment of major depression follows the guidelines from evidence-based medicine established algorithms; however, 50% of patients diagnosed with major depressive disorder do not respond to their first medication trial, and 70% may go through four treatment attempts before achieving remission.

Purpose: To demonstrate the value of pharmacogenomic testing as a treatment-guidance technology in patients with resistant depression and assess healthcare providers' motivation to adopt the technology.

Methods: A retrospective chart review of (N = 73) patients' treatment response measured by the pre-post PHQ-9 depression scale after pharmacogenomic guided medication intervention with descriptive statistics and paired t-test. The project also assessed providers' motivation to adopt and use pharmacogenomic testing by completing the providers' motivation scale (PMA) before and after viewing an educational session on the subject.

Results: A significant improvement in mood with a mean decrease of 10 points in the post PHQ-9 scores ( p = .000 < .001) in 53% of the subjects, and 33% had scores that ranked within remission. Most patients (60%) responded to 1.3 medications post pharmacogenomic treatment. The providers were motivated to learn new technology and gain knowledge derived from current information for patient care.

Conclusions: These are significant findings corresponding to the new evidence research in pharmacogenomics supporting the use of the technology as a therapeutic resource for treatment-resistant depression patients.

Keywords: pharmacogenomics, psychiatry, major depression, nursing,
innovation adoption

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Creative Commons License
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