Doctor of Nursing Practice (DNP) Projects
Access Control
Open Access
Embargo Period
4-19-2021
Degree Program
Doctor of Nursing Practice
Degree Track
Post Master's DNP Completion
Year Degree Awarded
2021
Month Degree Awarded
May
Keywords
Pharmacogenomics, psychiatry, major depression, nursing, innovation adoption
Advisor
Pamela Aselton PhD, MPH, FNP-BC
DNP Project Chair
Pamela Aselton PhD, MPH, FNP-BC
DNP Project Member Name
Jeungok Choi, RN, PhD MPH
DNP Project Outside Member Name
Louis A. Velazquez, MD, DFAPA
Abstract
Abstract
Background: Treatment of major depression follows the guidelines from evidence-based medicine established algorithms; however, 50% of patients diagnosed with major depressive disorder do not respond to their first medication trial, and 70% may go through four treatment attempts before achieving remission.
Purpose: To demonstrate the value of pharmacogenomic testing as a treatment-guidance technology in patients with resistant depression and assess healthcare providers' motivation to adopt the technology.
Methods: A retrospective chart review of (N = 73) patients' treatment response measured by the pre-post PHQ-9 depression scale after pharmacogenomic guided medication intervention with descriptive statistics and paired t-test. The project also assessed providers' motivation to adopt and use pharmacogenomic testing by completing the providers' motivation scale (PMA) before and after viewing an educational session on the subject.
Results: A significant improvement in mood with a mean decrease of 10 points in the post PHQ-9 scores ( p = .000 < .001) in 53% of the subjects, and 33% had scores that ranked within remission. Most patients (60%) responded to 1.3 medications post pharmacogenomic treatment. The providers were motivated to learn new technology and gain knowledge derived from current information for patient care.
Conclusions: These are significant findings corresponding to the new evidence research in pharmacogenomics supporting the use of the technology as a therapeutic resource for treatment-resistant depression patients.
Keywords: pharmacogenomics, psychiatry, major depression, nursing,
innovation adoption
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