This study identifies factors that affect tourism experience of people with mobility impairments, and examines how the interactions of factors formulate a positive/negative tourism experience. Both focus-group and personal interviews were conducted among twenty-three travelers with mobility impairments. Identified factors involve: physical environment (physical accessibility, convenience, security), human interaction environment (service capacity, service attitude, efficiency of services), individual characteristics (personality type, sensitivity to the environment) and situational factors. Among these factors, convenience, security, efficiency of services, personality type, sensitivity to the environment, as well as the situational factors were new content added to the existing conceptual framework. This study reveals that when physical factors fail, human interaction in most cases can compensate for it. Moreover, individual characteristics and situational factors affected participants’ engagement in physical and human interaction environment