Employing Self-determination Theory to explore travel motivational patterns among People with Mobility Challenges, this study extends the travel motivation conceptualization with a distinction of driving forces underlying travel motivations. The revealed variations in travel-facilitating effects and motivation-cultivating mechanisms across a spectrum of differentially driven motivations support the distinction. The cross-context reliability of the distinction was also checked through a challenge-level experimental manipulation. Specifically, the inner-driven self-determined motivations better facilitate PwMC’s travel pursuits when travel challenges are significant, whereas social-driven controlled motivations dominate travel facilitation at low-challenge levels. The support of autonomy, competence, and relatedness is found to facilitate both self-determined and controlled travel motivations, but setting self-determined pursuits apart from controlled pursuits at high-challenge levels. Moreover, this study introduces promising statistical approaches for competitively accurate and efficient comparison of correlated effects, useful for future applications in the tourism field.