Local residents are important stakeholders in tourism development. Their positive quality of life should be considered and ensured while destinations try to satisfy tourists and earn benefits from tourism. This paper examine residents’ perspectives at tourism destinations, specifically, the relationship between residents’ satisfaction with their quality of life related to tourism impacts and their support for tourism. The research site is a popular destination in the Southwest of the USA. Data were collected using a mail-back resident survey. The results of a structural equation modeling approach confirms the hypothesis that residents’ satisfaction with quality of life affects their level of support for further tourism development. However, the indicators and sub-constructs attributing to the residents’ satisfaction with quality of life could be varied, depending on features of each destination and demographics of the residents.