Publication Date
2023
Journal or Book Title
Frontiers in Cell and Developmental Biology
Abstract
The Six1 transcription factor plays important roles in the development of cranial sensory organs, and point mutations underlie craniofacial birth defects. Because Six1’s transcriptional activity can be modulated by interacting proteins, we previously screened for candidate interactors and identified zinc-finger MYM-containing protein 4 (Zmym4) by its inclusion of a few domains with a bona fide cofactor, Sine oculis binding protein (Sobp). Although Zmym4 has been implicated in regulating early brain development and certain cancers, its role in craniofacial development has not previously been described.
DOI
https://doi.org/10.3389/fcell.2023.1274788
Volume
11
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Jourdeuil, Karyn; Neilson, Karen M.; Cousin, Helene; Tavares, Andre L. P.; Majumdar, Himani D.; Alfandari, Dominique; and Moody, Sally A., "Zmym4 is required for early cranial gene expression and craniofacial cartilage formation" (2023). Frontiers in Cell and Developmental Biology. 25.
https://doi.org/10.3389/fcell.2023.1274788