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Author ORCID Identifier
https://orcid.org/0000-0001-6662-819X
AccessType
Campus-Only Access for Five (5) Years
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
Year Degree Awarded
2020
Month Degree Awarded
September
First Advisor
Igor A. Kaltashov
Subject Categories
Analytical Chemistry | Biochemistry
Abstract
Heparin and heparan sulfate (HS) are linear polyanions from the glycosaminoglycan (GAG) family. They are conceived to play critical roles in a variety of biophysiological processes by interacting with key proteins and regulating protein functions. Understanding their biological functions and exploit heparin’s unique versatility for therapeutic purposes critically depend on the characterization of their interactions with relevant proteins, which, however, is largely impeded by the structural heterogeneity of these polyanions. This work presented the development of novel mass spectrometry-based analytical strategies incorporated with liquid chromatography and ion mobility spectroscopy to investigate heparin-protein interactions and address their significance from different aspects.
DOI
https://doi.org/10.7275/18801450
Recommended Citation
Niu, Chendi, "NOVEL MASS SPECTROMETRY BASED STRATEGIES TO STUDY HEPARIN-PROTEIN INTERACTIONS" (2020). Doctoral Dissertations. 2067.
https://doi.org/10.7275/18801450
https://scholarworks.umass.edu/dissertations_2/2067