Journal

Dose-Response: An International Journal

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<h2><macro journal_styleguide_label></h2> <div id="styleguide"> <p>This document provides details on typesetting and layout requirements pertaining to final manuscript submission to <em><macro ir_journal.title encode='html'></em>.</p> <h3>Formatting Requirements</h3> <ul> <li>Do not include a title page or abstract. (Begin the document with the introduction; a title page, including the abstract, will be added to your paper by the editors.)</li> <li>Do not include page numbers, headers, or footers. These will be added by the editors.</li> <li>Write your article in English (unless the journal expressly permits non-English submissions).</li> <li>Submit your manuscript, including tables, figures, appendices, etc., as a single file (Word, <magic if test="my.AUTO_CONVERT_WORDPERFECT_FILE">WordPerfect, </magic><acronym title="Rich Text Format">RTF</acronym>, or <acronym title="Portable Document Format">PDF</acronym> files are accepted).</li> <li>Page size should be 8.5 x 11-inches.</li> <li>All margins (left, right, top and bottom) should be 1.5 inches (3.8 cm), including your tables and figures.</li> <li>Single space your text.</li> <li>Use a single column layout with both left and right margins justified.</li> <li>Font: <ol><li>Main Body&amp;#8212;12 pt. Times or the closest comparable font available</li> <li>Footnotes&amp;#8212;10 pt. Times or the closest comparable font available</li> </ol> </li> <li>If figures are included, use high-resolution figures, preferably encoded as encapsulated PostScript (eps).</li> <li>Copyedit your manuscript.</li> <li>When possible, there should be no pages where more than a quarter of the page is empty space.</li> </ul> <h3>Additional Recommendations</h3> <h4>Indenting, Line Spacing, and Justification</h4> <p><strong>Indent all paragraphs except those following a section heading.</strong> An indent should be at least 2 em-spaces.</p> <p>Do not insert extra space between paragraphs of text with the exception of long quotations, theorems, propositions, special remarks, etc. These should be set off from the surrounding text by additional space above and below. </p> <p>Don't "widow" or "orphan" text (i.e., ending a page with the first line of a paragraph or beginning a page with the last line of a paragraph).</p> <p>All text should be <strong>left-justified</strong> (i.e., flush with the left margin&amp;#8212;except where indented). Where possible, it should also be right-justified (i.e., flush with the right margin). "Where possible" refers to the quality of the justification. For example, <a href="https://www.latex-project.org" title="LaTeX project: LaTeX &amp;ndash; A document preparation system">LaTeX</a> and <a href="https://www.tug.org/" title="TeX Users Group (TUG) home page">TeX</a> do an excellent job of justifying text. Word does a reasonable job. But some word processors do a lousy job (e.g., they achieve right justification by inserting too much white space within and between words). We prefer flush right margins. However, it is better to have jagged right margins than to have flush right margins with awkward intra- and inter-word spacing. Make your decision on whichever looks best. </p> <h4>Language &amp;amp; Grammar</h4> <p>All submissions must be in English. Except for common foreign words and phrases, the use of foreign words and phrases should be avoided.</p> <p> Authors should use proper, standard English grammar. The <em>Elements of Style</em> by William Strunk, Jr. and E. B. White (now in its fourth edition) is the "standard" guide, but other excellent guides (e.g., <em>The Chicago Manual of Style</em>, University of Chicago Press) exist as well. </p> <h4>Article Length</h4> <p>Because this journal publishes electronically, page limits are not as relevant as they are in the world of print publications. We are happy, therefore, to let authors take advantage of this greater "bandwidth" to include material that they might otherwise have to cut to get into a print journal. This said, authors should exercise some discretion with respect to length.</p> <h4>Colored text</h4> <p>Set the <strong>font color to black</strong> for the majority of the text. We encourage authors to take advantage of the ability to use color in the production of figures, maps, etc., however, you need to appreciate that this will cause some of your readers problems when they print the document on a black &amp;amp; white printer. For this reason, you are advised to avoid the use of colors in situations where their translation to black and white would render the material illegible or incomprehensible.</p> <p>Please ensure that there are no colored mark-ups or comments in the final version, unless they are meant to be part of the final text. (You may need to "accept all changes" in track changes or set your document to "normal" in final markup.) </p> <h4>Emphasized text</h4> <p>Whenever possible use <em>italics</em> to indicate text you wish to emphasize rather than underlining it. The use of color to emphasize text is discouraged.</p> <h4>Font faces</h4><p>Except, possibly, where special symbols are needed, use Times or the closest comparable font available. If you desire a second font, for instance for headings, use a sans serif font (e.g., Arial or Computer Modern Sans Serif). </p> <h4>Font size</h4> <p>The main body of text should be set in 12pt. Avoid the use of fonts smaller than 6pt.</p> <h4>Foreign terms</h4> <p>Whenever possible, foreign terms should be set in <em>italics</em> rather than underlined.</p> <h4>Headings</h4> <p><strong>Headings</strong> (e.g., start of sections) should be distinguished from the main body text by their fonts or by using small caps. Use the same font face for all headings and indicate the hierarchy by reducing the font size. There should be space above and below headings.</p> <h4>Main text </h4> <p>The font for the <strong>main body</strong> of text must be black and, if at all possible, in Times or closest comparable font available. </p> <h4>Titles</h4> <p>Whenever possible, <strong>titles of books, movies, etc.</strong>, should be set in <em>italics</em> rather than underlined.</p> <h4>Footnotes</h4> <p><strong>Footnotes</strong> should appear at the bottom of the page on which they are referenced rather than at the end of the paper. Footnotes should be in 10 pt. Times or closest comparable font available, they should be single spaced, and there should be a footnote separator rule (line). Footnote numbers or symbols in the text must follow, rather than precede, punctuation. Excessively long footnotes are probably better handled in an appendix. All footnotes should be left and right-justified (i.e., flush with the right margin), unless this creates awkward spacing.</p> <h4>Tables and Figures</h4> <p>To the extent possible, <strong>tables and figures</strong> should appear in the document near where they are referenced in the text. Large tables or figures should be put on pages by themselves. Avoid the use of overly small type in tables. In no case should tables or figures be in a separate document or file. All tables and figures must fit within 1.5" margins on all sides (top, bottom, left and right) in both portrait and landscape view.</p> <h4>Mathematics</h4> <p><strong>Roman letters</strong> used in mathematical expressions as variables should be <em>italicized</em>. Roman letters used as part of multi-letter function names should not be italicized. Whenever possible, subscripts and superscripts should be a smaller font size than the main text. </p> <p><strong>Short mathematical expressions</strong> should be typed inline. <strong>Longer expressions</strong> should appear as display math. Also expressions using many different levels (e.g., such as the fractions) should be set as display math. Important definitions or concepts can also be set off as display math. </p> <p><strong>Equations</strong> should be numbered sequentially. Whether equation numbers are on the right or left is the choice of the author(s). However, you are expected to be consistent in this. </p> <p><strong>Symbols and notation</strong> in unusual fonts should be avoided. This will not only enhance the clarity of the manuscript, but it will also help insure that it displays correctly on the reader's screen and prints correctly on her printer. When proofing your document under <acronym title="Portable Document Format">PDF</acronym> pay particular attention to the rendering of the mathematics, especially symbols and notation drawn from other than standard fonts. </p> <h2 id="bibliography">References</h2> <p>It is the author's obligation to provide complete references with the necessary information. After the last sentence of your submission, please insert a line break&amp;#8212;not a page break&amp;#8212;and begin your references on the same page, if possible. References should appear right after the end of the document, beginning on the last page if possible. References should have margins that are both left and right- justified. You may choose not to right-justify the margin of one or more references if the spacing looks too awkward. Each reference should give the last names of all the authors, their first names or first initials, and, optionally, their middle initials. The hierarchy for ordering the references is:</p> <ol> <li> Last name of first author </li> <li> First name of first author <li> Last name of second author (if any). Co-authored work is listed after solo-authored work by the same first author (e.g., Edlin, Aaron S. would precede Edlin, Aaron S. and Stefan Reichelstein).</li> <li> First name of second author</li> <li> Publication date</li> <li> Order cited in text</li> </ol><p> The information to be given with each citation in the references is as follows:</p> <h4>Articles in traditional journals:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of article, name of journal, year of publication (or "n.d." if no date), volume number, page numbers. </p> <p><em>Optional (but desirable)</em>: issue number and month/season of publication. For forthcoming (in press) articles, put expected year of publication and substitute "forthcoming" for the volume and page numbers.</p> <p><em>Optional(but desirable)</em>: A hyperlink to the article.</p> <h4>Books:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of book, year of publication (or "n.d." if no date), publisher, publisher's address, edition (if not first). For forthcoming (in press) books, put expected year of publication and add "forthcoming."</p> <h4>Chapters in collections or anthologies:</h4> <p><strong>Required:</strong> Name(s) of author(s) of chapter, name(s) of editor(s) of book, title of chapter, title of book, year of publication (or "n.d." if no date), publisher, publisher's address, and edition (if not first). For forthcoming (in press) books, put expected year of publication and add "forthcoming."</p> <h4>Working papers:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of working paper, year (or "n.d." if no date), location (e.g., "Department of Economics Working Paper, University of California, Berkeley" or "Author's web site: http://www.someurl.edu/author." If the working paper is part of series, then the series name and the number of the working paper within the series must also be given.</p> <h4>Other works:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of work, year (or "n.d." if no date), and information about how the reader could obtain a copy.</p> <p>Within the references section, the citations can be formatted as you like, provided (i) the formatting is consistent and (ii) each citation begins with the last name of the first author. That is, the following would all be acceptable:</p> <div class="example"> <pre>Smith, Adam (1776) The Wealth of Nations, . . .</pre> <pre>Smith, A., The Wealth of Nations, . . . , 1776. </pre> <pre>Smith, Adam: The Wealth of Nations, 1776, . . .</pre> </div><div class="clear">&amp;nbsp;</div> <p>Use hanging indents for citations (i.e., the first line of the citation should be flush with the left margin and all other lines should be indented from the left margin by a set amount). Citations should be single-spaced with extra space between citations.</p> <p>When works by the same author are listed in a row, use &amp;#8212; instead of writing the name again. Hence, one might have</p> <div class="example"> <pre>Smith, Adam: The Wealth of Nations, . . .</pre> <pre>&amp;#8212;: The Theory of Moral Sentiments, . . . </pre></div><div class="clear">&amp;nbsp;</div> <p>Similarly, instead of repeating two names use</p> <div class="example"> <pre>"&amp;#8212; and &amp;#8212;."</pre></div> <p>For instance,</p> <div class="example"><pre>Edlin, A. and S. Reichelstein (1995) . . . &amp;#8212; and &amp;#8212; (1996) . . . </pre></div> <div class="clear">&amp;nbsp;</div> <p>Within the text of your manuscript, use the <strong>author-date</strong> method of citation. For instance, </p> <div class="example"> <pre>"As noted by Smith (1776)." </pre> </div><div class="clear">&amp;nbsp;</div> <p>When there are two authors, use both last names. For instance,</p> <div class="example"> <pre>"Edlin and Reichelstein (1996) claim . . . "</pre> </div> <div class="clear">&amp;nbsp;</div> <p>If there are three or more authors give the last name of the first author and append et al. For instance, a 1987 work by Abel, Baker, and Charley, would be cited as</p> <div class="example"> <pre>"Abel et al. (1987)." </pre> </div> <div class="clear">&amp;nbsp;</div> <p>If two or more cited works share the same authors and dates, use "a," "b," and so on to distinguish among them. For instance,</p> <div class="example"> <pre>"Jones (1994b) provides a more general analysis of the model introduced in Example 3 of Jones (1994a)."</pre></div> <div class="clear">&amp;nbsp;</div> <p>After the first cite in the text using the author-date method, subsequent cites can use just the last names if that would be unambiguous. For example, Edlin and Reichelstein (1996) can be followed by just Edlin and Reichelstein provided no other Edlin &amp;amp; Reichelstein article is referenced; if one is, then the date must always be attached.</p> <p>When citations appear within parentheses, use commas&amp;#8212;rather than parentheses or brackets&amp;#8212;to separate the date from the surrounding text. For instance, </p> <div class="example"> <pre>" ...(see Smith, 1776, for an early discussion of this)."</pre></div> <div class="clear">&amp;nbsp;</div> </div>

Search Results

Now showing 1 - 10 of 402
  • PublicationOpen Access
  • PublicationOpen Access
    Dose-Response, Vol 11, no 4
    (2013-12-01)
  • PublicationOpen Access
    ADAPTATION AND SENSITIZATION TO PROTEOTOXIC STRESS
    (2014-03-31) Leak, Rehana K.
    Although severe stress can elicit toxicity, mild stress often elicits adaptations. Here we review the literature on stress-induced adaptations versus stress sensitization in models of neurodegenerative diseases. We also describe our recent findings that chronic proteotoxic stress can elicit adaptations if the dose is low but that high-dose proteotoxic stress sensitizes cells to subsequent challenges. In these experiments, long-term, low-dose proteasome inhibition elicited protection in a superoxide dismutase-dependent manner. In contrast, acute, high-dose proteotoxic stress sensitized cells to subsequent proteotoxic challenges by eliciting catastrophic loss of glutathione. However, even in the latter model of synergistic toxicity, several defensive proteins were upregulated by severe proteotoxicity. This led us to wonder whether high-dose proteotoxic stress can elicit protection against subsequent challenges in astrocytes, a cell type well known for their resilience. In support of this new hypothesis, we found that the astrocytes that survived severe proteotoxicity became harder to kill. The adaptive mechanism was glutathione dependent. If these findings can be generalized to the human brain, similar endogenous adaptations may help explain why neurodegenerative diseases are so delayed in appearance and so slow to progress. In contrast, sensitization to severe stress may explain why defenses eventually collapse in vulnerable neurons.
  • PublicationOpen Access
    EFFECT OF LOW DOSES OF LOW-LET RADIATION ON THE INNATE ANTITUMOR REACTIONS IN RADIORESISTANT AND RADIOSENSITIVE MICE
    (2012-12-01) Nowosielska, Ewa M.; Cheda, Aneta; Wrembel-Wargocka, Jolanta; Janiak, Marek K.
    BALB/c and C57BL/6 mice differ in their Th1/Th2 lymphocyte and M1/M2 macrophage phenotypes, radiosensitivity, and post-irradiation tumor incidence. In this study we evaluated the effects of repeated low-level exposures to X-rays on the development of artificial tumor colonies in the lungs of animals from the two strains and cytotoxic activities of natural killer (NK) cells and macrophages obtained from these mice. After ten daily irradiations of BALB/c or C57BL/6 mice with 0.01, 0.02, and 0.1 Gy X-rays NK cell-enriched splenocytes collected from the animals demonstrated significant and comparable up-regulation of their anti-tumor cytotoxic function. Likewise, peritoneal macrophages collected from the two irradiated strains of mice exhibited the similarly stimulated cytotoxicities against susceptible tumor cells and produced significantly more nitric oxide. These results were accompanied by the significantly reduced numbers of the neoplastic colonies induced in the lungs by intravenous injection of syngeneic tumor cells. The obtained results indicate that ten low-level irradiations with X-rays stimulate the generally similar anti-tumor reactions in BALB/c and C57BL/6 mice.
  • PublicationOpen Access
  • PublicationOpen Access
    HORMESIS IS APPLICABLE AS A PRO-HEALTHY AGING INTERVENTION IN MAMMALS AND HUMAN BEINGS
    (2010-03-01) Pardon, Marie-Christine
    The aging of the population brings new heath challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension strategy and how it can be applied to the human. There is some evidence that the anti-aging benefits of lifestyle factors, such as diet, exercise or engaging in activities may be achieved via hormetic regulation. This supports the validity of the concept in human. There are, however, gaps in knowledge and ethical barriers that need to be addressed to establish the suitability of the approach to the clinical context or the general geriatric population. In particular, we need to find out which stressors are safe for use as anti-aging interventions, when they have to be applied to achieve maximal benefits, how their therapeutic potential is altered by changes in the stress system induced by age and pathological conditions, and the extent to which the occurrence of adverse versus positive effects depends on interacting genetic and experiential factors.
  • PublicationMetadata only
  • PublicationOpen Access
  • PublicationOpen Access
  • PublicationOpen Access
    MODELING DNA DOUBLE-STRAND BREAK REPAIR KINETICS AS AN EPIREGULATED CELL-COMMUNITY-WIDE (EPICELLCOM) RESPONSE TO RADIATION STRESS
    (2011-12-01) Scott, Bobby R
    The multicellular signaling model (MULTISIG1) was recently introduced to simulate the kinetics of repair of DNA double-strand breaks (DSBs) that were induced in confluent (non-dividing) cultured cells by a very low radiation dose where at most a single induced DSB would be expected in a given cell nucleus. The repair kinetics was modeled as representing what is now called an epigenetically-regulated (epiregulated) cell-community-wide (epicellcom) response to radiation stress. DSB repair initiation is assumed to require a threshold number of cells with DSBs participating in intercellular stress-response signaling. The MULTISIG1 model is extended in this study to apply to moderate doses where several DSBs can occur on the same DNA molecule. The repair of multiple breaks on the same molecule is treated as sequential stochastic events. For cells of differing genetic characteristics and epigenetic statuses, relationships are provided for evaluating the relative susceptibility (RS) for DSB induction, relative repair capacity (RRC) for DSB repair, and relative epiapoptosis capacity (REC), for epigenetically regulated apoptosis. The modified MULTISIG1 model is used to characterize the expected repair kinetics for confluent, human lung fibroblasts (MRC-5 line) briefly exposed in vitro to 90-kV x-rays. Possible application of the model to biological dosimetry is also discussed.