Dose-Response: An International Journal

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<h2><macro journal_styleguide_label></h2> <div id="styleguide"> <p>This document provides details on typesetting and layout requirements pertaining to final manuscript submission to <em><macro ir_journal.title encode='html'></em>.</p> <h3>Formatting Requirements</h3> <ul> <li>Do not include a title page or abstract. (Begin the document with the introduction; a title page, including the abstract, will be added to your paper by the editors.)</li> <li>Do not include page numbers, headers, or footers. These will be added by the editors.</li> <li>Write your article in English (unless the journal expressly permits non-English submissions).</li> <li>Submit your manuscript, including tables, figures, appendices, etc., as a single file (Word, <magic if test="my.AUTO_CONVERT_WORDPERFECT_FILE">WordPerfect, </magic><acronym title="Rich Text Format">RTF</acronym>, or <acronym title="Portable Document Format">PDF</acronym> files are accepted).</li> <li>Page size should be 8.5 x 11-inches.</li> <li>All margins (left, right, top and bottom) should be 1.5 inches (3.8 cm), including your tables and figures.</li> <li>Single space your text.</li> <li>Use a single column layout with both left and right margins justified.</li> <li>Font: <ol><li>Main Body&amp;#8212;12 pt. Times or the closest comparable font available</li> <li>Footnotes&amp;#8212;10 pt. Times or the closest comparable font available</li> </ol> </li> <li>If figures are included, use high-resolution figures, preferably encoded as encapsulated PostScript (eps).</li> <li>Copyedit your manuscript.</li> <li>When possible, there should be no pages where more than a quarter of the page is empty space.</li> </ul> <h3>Additional Recommendations</h3> <h4>Indenting, Line Spacing, and Justification</h4> <p><strong>Indent all paragraphs except those following a section heading.</strong> An indent should be at least 2 em-spaces.</p> <p>Do not insert extra space between paragraphs of text with the exception of long quotations, theorems, propositions, special remarks, etc. These should be set off from the surrounding text by additional space above and below. </p> <p>Don't "widow" or "orphan" text (i.e., ending a page with the first line of a paragraph or beginning a page with the last line of a paragraph).</p> <p>All text should be <strong>left-justified</strong> (i.e., flush with the left margin&amp;#8212;except where indented). Where possible, it should also be right-justified (i.e., flush with the right margin). "Where possible" refers to the quality of the justification. For example, <a href="https://www.latex-project.org" title="LaTeX project: LaTeX &amp;ndash; A document preparation system">LaTeX</a> and <a href="https://www.tug.org/" title="TeX Users Group (TUG) home page">TeX</a> do an excellent job of justifying text. Word does a reasonable job. But some word processors do a lousy job (e.g., they achieve right justification by inserting too much white space within and between words). We prefer flush right margins. However, it is better to have jagged right margins than to have flush right margins with awkward intra- and inter-word spacing. Make your decision on whichever looks best. </p> <h4>Language &amp;amp; Grammar</h4> <p>All submissions must be in English. Except for common foreign words and phrases, the use of foreign words and phrases should be avoided.</p> <p> Authors should use proper, standard English grammar. The <em>Elements of Style</em> by William Strunk, Jr. and E. B. White (now in its fourth edition) is the "standard" guide, but other excellent guides (e.g., <em>The Chicago Manual of Style</em>, University of Chicago Press) exist as well. </p> <h4>Article Length</h4> <p>Because this journal publishes electronically, page limits are not as relevant as they are in the world of print publications. We are happy, therefore, to let authors take advantage of this greater "bandwidth" to include material that they might otherwise have to cut to get into a print journal. This said, authors should exercise some discretion with respect to length.</p> <h4>Colored text</h4> <p>Set the <strong>font color to black</strong> for the majority of the text. We encourage authors to take advantage of the ability to use color in the production of figures, maps, etc., however, you need to appreciate that this will cause some of your readers problems when they print the document on a black &amp;amp; white printer. For this reason, you are advised to avoid the use of colors in situations where their translation to black and white would render the material illegible or incomprehensible.</p> <p>Please ensure that there are no colored mark-ups or comments in the final version, unless they are meant to be part of the final text. (You may need to "accept all changes" in track changes or set your document to "normal" in final markup.) </p> <h4>Emphasized text</h4> <p>Whenever possible use <em>italics</em> to indicate text you wish to emphasize rather than underlining it. The use of color to emphasize text is discouraged.</p> <h4>Font faces</h4><p>Except, possibly, where special symbols are needed, use Times or the closest comparable font available. If you desire a second font, for instance for headings, use a sans serif font (e.g., Arial or Computer Modern Sans Serif). </p> <h4>Font size</h4> <p>The main body of text should be set in 12pt. Avoid the use of fonts smaller than 6pt.</p> <h4>Foreign terms</h4> <p>Whenever possible, foreign terms should be set in <em>italics</em> rather than underlined.</p> <h4>Headings</h4> <p><strong>Headings</strong> (e.g., start of sections) should be distinguished from the main body text by their fonts or by using small caps. Use the same font face for all headings and indicate the hierarchy by reducing the font size. There should be space above and below headings.</p> <h4>Main text </h4> <p>The font for the <strong>main body</strong> of text must be black and, if at all possible, in Times or closest comparable font available. </p> <h4>Titles</h4> <p>Whenever possible, <strong>titles of books, movies, etc.</strong>, should be set in <em>italics</em> rather than underlined.</p> <h4>Footnotes</h4> <p><strong>Footnotes</strong> should appear at the bottom of the page on which they are referenced rather than at the end of the paper. Footnotes should be in 10 pt. Times or closest comparable font available, they should be single spaced, and there should be a footnote separator rule (line). Footnote numbers or symbols in the text must follow, rather than precede, punctuation. Excessively long footnotes are probably better handled in an appendix. All footnotes should be left and right-justified (i.e., flush with the right margin), unless this creates awkward spacing.</p> <h4>Tables and Figures</h4> <p>To the extent possible, <strong>tables and figures</strong> should appear in the document near where they are referenced in the text. Large tables or figures should be put on pages by themselves. Avoid the use of overly small type in tables. In no case should tables or figures be in a separate document or file. All tables and figures must fit within 1.5" margins on all sides (top, bottom, left and right) in both portrait and landscape view.</p> <h4>Mathematics</h4> <p><strong>Roman letters</strong> used in mathematical expressions as variables should be <em>italicized</em>. Roman letters used as part of multi-letter function names should not be italicized. Whenever possible, subscripts and superscripts should be a smaller font size than the main text. </p> <p><strong>Short mathematical expressions</strong> should be typed inline. <strong>Longer expressions</strong> should appear as display math. Also expressions using many different levels (e.g., such as the fractions) should be set as display math. Important definitions or concepts can also be set off as display math. </p> <p><strong>Equations</strong> should be numbered sequentially. Whether equation numbers are on the right or left is the choice of the author(s). However, you are expected to be consistent in this. </p> <p><strong>Symbols and notation</strong> in unusual fonts should be avoided. This will not only enhance the clarity of the manuscript, but it will also help insure that it displays correctly on the reader's screen and prints correctly on her printer. When proofing your document under <acronym title="Portable Document Format">PDF</acronym> pay particular attention to the rendering of the mathematics, especially symbols and notation drawn from other than standard fonts. </p> <h2 id="bibliography">References</h2> <p>It is the author's obligation to provide complete references with the necessary information. After the last sentence of your submission, please insert a line break&amp;#8212;not a page break&amp;#8212;and begin your references on the same page, if possible. References should appear right after the end of the document, beginning on the last page if possible. References should have margins that are both left and right- justified. You may choose not to right-justify the margin of one or more references if the spacing looks too awkward. Each reference should give the last names of all the authors, their first names or first initials, and, optionally, their middle initials. The hierarchy for ordering the references is:</p> <ol> <li> Last name of first author </li> <li> First name of first author <li> Last name of second author (if any). Co-authored work is listed after solo-authored work by the same first author (e.g., Edlin, Aaron S. would precede Edlin, Aaron S. and Stefan Reichelstein).</li> <li> First name of second author</li> <li> Publication date</li> <li> Order cited in text</li> </ol><p> The information to be given with each citation in the references is as follows:</p> <h4>Articles in traditional journals:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of article, name of journal, year of publication (or "n.d." if no date), volume number, page numbers. </p> <p><em>Optional (but desirable)</em>: issue number and month/season of publication. For forthcoming (in press) articles, put expected year of publication and substitute "forthcoming" for the volume and page numbers.</p> <p><em>Optional(but desirable)</em>: A hyperlink to the article.</p> <h4>Books:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of book, year of publication (or "n.d." if no date), publisher, publisher's address, edition (if not first). For forthcoming (in press) books, put expected year of publication and add "forthcoming."</p> <h4>Chapters in collections or anthologies:</h4> <p><strong>Required:</strong> Name(s) of author(s) of chapter, name(s) of editor(s) of book, title of chapter, title of book, year of publication (or "n.d." if no date), publisher, publisher's address, and edition (if not first). For forthcoming (in press) books, put expected year of publication and add "forthcoming."</p> <h4>Working papers:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of working paper, year (or "n.d." if no date), location (e.g., "Department of Economics Working Paper, University of California, Berkeley" or "Author's web site: http://www.someurl.edu/author." If the working paper is part of series, then the series name and the number of the working paper within the series must also be given.</p> <h4>Other works:</h4> <p><strong>Required:</strong> Author's (authors') name(s), title of work, year (or "n.d." if no date), and information about how the reader could obtain a copy.</p> <p>Within the references section, the citations can be formatted as you like, provided (i) the formatting is consistent and (ii) each citation begins with the last name of the first author. That is, the following would all be acceptable:</p> <div class="example"> <pre>Smith, Adam (1776) The Wealth of Nations, . . .</pre> <pre>Smith, A., The Wealth of Nations, . . . , 1776. </pre> <pre>Smith, Adam: The Wealth of Nations, 1776, . . .</pre> </div><div class="clear">&amp;nbsp;</div> <p>Use hanging indents for citations (i.e., the first line of the citation should be flush with the left margin and all other lines should be indented from the left margin by a set amount). Citations should be single-spaced with extra space between citations.</p> <p>When works by the same author are listed in a row, use &amp;#8212; instead of writing the name again. Hence, one might have</p> <div class="example"> <pre>Smith, Adam: The Wealth of Nations, . . .</pre> <pre>&amp;#8212;: The Theory of Moral Sentiments, . . . </pre></div><div class="clear">&amp;nbsp;</div> <p>Similarly, instead of repeating two names use</p> <div class="example"> <pre>"&amp;#8212; and &amp;#8212;."</pre></div> <p>For instance,</p> <div class="example"><pre>Edlin, A. and S. Reichelstein (1995) . . . &amp;#8212; and &amp;#8212; (1996) . . . </pre></div> <div class="clear">&amp;nbsp;</div> <p>Within the text of your manuscript, use the <strong>author-date</strong> method of citation. For instance, </p> <div class="example"> <pre>"As noted by Smith (1776)." </pre> </div><div class="clear">&amp;nbsp;</div> <p>When there are two authors, use both last names. For instance,</p> <div class="example"> <pre>"Edlin and Reichelstein (1996) claim . . . "</pre> </div> <div class="clear">&amp;nbsp;</div> <p>If there are three or more authors give the last name of the first author and append et al. For instance, a 1987 work by Abel, Baker, and Charley, would be cited as</p> <div class="example"> <pre>"Abel et al. (1987)." </pre> </div> <div class="clear">&amp;nbsp;</div> <p>If two or more cited works share the same authors and dates, use "a," "b," and so on to distinguish among them. For instance,</p> <div class="example"> <pre>"Jones (1994b) provides a more general analysis of the model introduced in Example 3 of Jones (1994a)."</pre></div> <div class="clear">&amp;nbsp;</div> <p>After the first cite in the text using the author-date method, subsequent cites can use just the last names if that would be unambiguous. For example, Edlin and Reichelstein (1996) can be followed by just Edlin and Reichelstein provided no other Edlin &amp;amp; Reichelstein article is referenced; if one is, then the date must always be attached.</p> <p>When citations appear within parentheses, use commas&amp;#8212;rather than parentheses or brackets&amp;#8212;to separate the date from the surrounding text. For instance, </p> <div class="example"> <pre>" ...(see Smith, 1776, for an early discussion of this)."</pre></div> <div class="clear">&amp;nbsp;</div> </div>

Search Results

Now showing 1 - 10 of 402
  • Publication
    DISSECTION OF THE HORMETIC CURVE: ANALYSIS OF COMPONENTS AND MECHANISMS
    (2014-09-01) Lushchak, Volodymyr I
    The relationship between the dose of an effector and the biological response frequently is not described by a linear function and, moreover, in some cases the doseresponse relationship may change from positive/adverse to adverse/positive with increasing dose. This complicated relationship is called “hormesis”. This paper provides a short analysis of the concept along with a description of used approaches to characterize hormetic relationships. The whole hormetic curve can be divided into three zones: I – a lag-zone where no changes are observed with increasing dose; II – a zone where beneficial/ adverse effects are observed, and III – a zone where the effects are opposite to those seen in zone II. Some approaches are proposed to analyze the molecular components involved in the development of the hormetic character of dose-response relationships with the use of specific genetic lines or inhibitors of regulatory pathways. The discussion is then extended to suggest a new parameter (half-width of the hormetic curve at zone II) for quantitative characterization of the hormetic curve. The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship.
  • Publication
    SMALL γ-RAY DOSES PREVENT RATHER THAN INCREASE LUNG TUMORS IN MICE
    (2012-12-01) Scott, B.R.; Bruce, V.R.; Gott, K.M.; Wilder, J.; March, T.
    We show evidence for low doses of γ rays preventing spontaneous hyperplastic foci and adenomas in the lungs of mice, presumably via activating natural anticancer defenses. The evidence partly relates to a new study we conducted whereby a small number of female A/J mice received 6 biweekly dose fractions (100 mGy per fraction) of γ rays to the total body which prevented the occurrence of spontaneous hyperplastic foci in the lung. We also analyzed data from a much earlier Oak Ridge National Laboratory study involving more than 10,000 female RFMf/Un mice whereby single γ-ray doses from 100 to 1,000 mGy prevented spontaneous lung adenomas. We point out the possibility that the decrease in lung cancer mortality observed in The National Lung Screening Trial Research Team study involving lung tumor screening using low-dose computed tomography (CT) may relate at least in part to low-dose X-rays activating the body’s natural anticancer defenses (i.e., radiation hormesis). This possibility was apparently not recognized by the indicated research team.
  • Publication
    COGNITIVE ACTIVATION BY CENTRAL THALAMIC STIMULATION: THE YERKES-DODSON LAW REVISITED
    (2011-09-01) Mair, Robert G; Onos, Kristen D; Hembrook, Jacqueline R
    Central thalamus regulates forebrain arousal, influencing activity in distributed neural networks that give rise to organized actions during alert, wakeful states. Central thalamus has been implicated in working memory by the effects of lesions and microinjected drugs in this part of the brain. Lesions and drugs that inhibit neural activity have been found to impair working memory. Drugs that increase activity have been found to enhance and impair memory depending on the dose tested. Electrical deep brain stimulation (DBS) similarly enhances working memory at low stimulating currents and impairs it at higher currents. These effects are time dependent. They were observed when DBS was applied during the memory delay (retention) or choice response (retrieval) but not earlier in trials during the sample (acquisition) phase. The effects of microinjected drugs and DBS are consistent with the Yerkes-Dodson law, which describes an inverted-U relationship between arousal and behavioral performance. Alternatively these results may reflect desensitization associated with higher levels of stimulation, spread of drugs or current to adjacent structures, or activation of less sensitive neurons or receptors at higher DBS currents or drug doses.
  • Publication
    NON-PROBLEMATIC RISKS FROM LOW-DOSE RADIATION-INDUCED DNA DAMAGE CLUSTERS
    (2008-03-01) Hayes, Daniel P
    Radiation-induced DNA damage clusters have been proposed and are usually considered to pose the threat of serious biological damage. This has been attributed to DNA repair debilitation or cessation arising from the complexity of cluster damage. It will be shown here, contrary to both previous suggestions and perceived wisdom, that radiation induced damage clusters contribute to non-problematic risks in the low-dose, low-LET regime. The very complexity of cluster damage which inhibits and/or compromises DNA repair will ultimately be responsible for the elimination and/or diminution of precancerous and cancerous cells.
  • Publication
    Dose-Response, Vol 10, no 4, Cover
    (2012-12-01)
  • Publication
    LUNG CANCER IN OREGON
    (2011-09-01) Hart, John
    Factors thought to be related to lung cancer include smoking, radon, and educational attainment. These factors were analyzed in the present ecological study for Oregon with correlation and linear regression statistics. A moderate, inverse, and statistically significant correlation was found with educational attainment while surprisingly, negligible and statistically insignificant correlations were found with smoking and radon. More rigorous research such as case-control study designs, are indicated to verify or refute these findings.
  • Publication
    EFFECT OF LOW DOSE RADIATION ON DIFFERENTIATION OF BONE MARROW CELLS INTO DENDRITIC CELLS
    (2013-09-01) Chun, Sung Hak; Park, Ga-Young; Han, Yu Kyeong; Kim, Sung Dae; Kim, Joong Sun; Lee, Chang Geun; Yang, Kwangmo
    Low dose radiation has been shown to be beneficial to living organisms using several biological systems, including immune and hematopoietic systems. Chronic low dose radiation was shown to stimulate immune systems, resulting in controlling the proliferation of cancer cells, maintain immune balance and induce hematopoietic hormesis. Since dendritic cells are differentiated from bone marrow cells and are key players in maintaining the balance between immune activation and tolerance, it may be important to further characterize whether low dose radiation can influence the capacity of bone marrow cells to differentiate into dendritic cells. We have shown that bone marrow cells from low dose- irradiated (γ-radiation, 0.2Gy, 15.44mGy/h) mice can differentiate into dendritic cells that have several different characteristics, such as expression of surface molecules, cytokine secretion and antigen uptake capacity, when compared to dentritic cells differentiated from the control bone marrow cells. These differences observed in the low dose radiation group can be beneficial to living organisms either by activation of immune responses to foreign antigens or tumors, or maintenance of self-tolerance. To the best of our knowledge, this is the first report showing that total-body low dose radiation can modulate the capacity of bone marrow cells to differentiate into dendritic cells.
  • Publication
  • Publication
    INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR
    (2013-06-01) Mortazavi, SMJ; Mosleh-Shirazi, MA; Tavassoli, AR; Taheri, M; Mehdizadeh, AR; Namazi, SAS; Jamali, A; Ghalandari, R; Bonyadi, S; Haghani, M; Shafie, M
    The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1st phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2nd phase, 30 male rats were divided into 2 groups of 15 animals. The 1st group received microwave exposure. The 2nd group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response.
  • Publication
    A PERSPECTIVE ON THE SCIENTIFIC, PHILOSOPHICAL, AND POLICY DIMENSIONS OF HORMESIS
    (2009-03-01) Hoffmann, George R
    The hormesis concept has broad implications for biology and the biomedical sciences. This perspective on hormesis concentrates on toxicology and toxicological risk assessment and secondarily explores observations from other fields. It considers the varied manifestations of hormesis in the context of a broad family of biological stress responses. Evidence for hormesis is reviewed, and the hormesis model is contrasted with more widely accepted dose-response models in toxicology: a linear nonthreshold (LNT) model for mutagenesis and carcinogenesis, and a threshold model for most other toxicologic effects. Scientific, philosophical, and political objections to the hormesis concept are explored, and complications in the hormesis concept are analyzed. The review concludes with a perspective on the current state of hormesis and challenges that the hormesis model poses for risk assessment.