Publication Date
2019
Journal or Book Title
International Journal of Molecular Medicine
Abstract
Processed products from agricultural produce generate a large number of agricultural by‑products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti‑photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)‑irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation‑induced expression of matrix metalloproteinase (MMP)‑2, MMP‑9, MMP‑3 and MMP‑13. Reverse transcription‑quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB‑induced expression of the genes encoding tumor necrosis factor‑α, inducible nitric oxide synthase, interleukin (IL)‑6 and IL‑1β when compared with the UVB‑vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB‑induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB‑vehicle group (P<0.05). These results reveal that fermented agricultural by‑products may serve as potential functional materials with anti‑photoaging activities.
DOI
http://dx.doi.org/10.3892/ijmm.2019.4242
Pages
559-568
Volume
44
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Choi, Sun-Il; Jung, Tae-Dong; Cho, Bong-Yeon; Choi, Seung-Hyun; Sim, Wan-Sup; Hao, Xionggao; Lee, Sang Jong; Kim, Young-Cheul; and Lee, Ok-Hwan, "Anti-photoaging effect of fermented agricultural by-products on ultraviolet B-irradiated hairless mouse skin" (2019). International Journal of Molecular Medicine. 225.
http://dx.doi.org/10.3892/ijmm.2019.4242