The current study investigated the effects of work-family conflict (WFC) on job and life satisfaction among hotel sales managers in China. Data were collected by a field survey on 121 sales managers in 26 hotels at the Pearl River Delta in China. A hierarchical regression analysis by GLM-Multivariate was conducted to test the hypotheses. The results indicated that in contract to the study hypotheses, hotel sales managers’ WIF (work interfering with family) had negative effects on job satisfaction but not life satisfaction, whereas FIW (family interfering with work) had negative effects on life satisfaction rather than job satisfaction. The results suggested the strategic role of family-friendly HR polices in hotel business and also remind potential limitations to the audience when implying the results in other hotels.